The Scudetto holders will meet last term’s runners-up on the weekend of August 30, while there will be a Milan derby on matchday three
Serie A champions Juventus will face rivals Roma on the second weekend of the new season.
The Bianconeri, who are bidding for a fifth successive Scudetto, have beaten the Giallorossi into second place for the past two years but must travel to the Stadio Olimpico on the weekend of August 30.
In what is set to be an exciting start to the 2015-16 campaign, free-spending duo AC Milan and Inter will lock horns in the Derby della Madonnina on matchday three.
Juve will begin their title defence with a home game against Udinese on either August 22 or 23, while Roma will open with a tricky trip to Verona.
Roberto Mancini’s Inter, who are set to continue their summer spending spree with the addition of Manchester City attacker Stevan Jovetic, will kick off their campaign against Atalanta at San Siro.
Meanwhile, new Milan boss Sinisa Mihajlovic faces a difficult opening assignment, with the Rossoneri having to travel to the Stadio Artemio Franchio to take on Fiorentina.
Maurizio Sarri, who replaced Rafael Benitez as Napoli coach after a fine season at Empoli, will take the Partenopei to Sassuolo on the opening weekend.
Elsewhere, newly-promoted Bologna have been handed a difficult opening fixture at Lazio, who finished third last season.
Serie A newcomers Frosinone and Carpi begin against Torino and Sampdoria, respectively.
Serie A 2015-16 – Round 1 – August 22/23
Empoli – Chievo
Fiorentina – AC Milan
Frosinone – Torino
Inter – Atalanta
Juventus – Udinese
Lazio – Bologna
Palermo – Genoa
Sampdoria – Carpi
Sassuolo – Napoli
Verona – Roma